> 실험동물 > Humanized Mouse  새론바이오는 일본 CIEA (Central Institute for Experimental Animals)의 NOG 마우스를 공급합니다.    NOG mouse   Developed by CIEA in 2002  Mamoru Ito, D.V.M., Ph.D.   Formal name  NOD.Cg-Prkdcscid II2rgtm1Sug/Jic   Abbreviated name  NOD/Shi-scid,IL-2Rγnull (NOD-scidIl2Rgnull, NOD scid gamma)   Japanese patent No.  No. 3,753,321   US patent No.  No. 7,145,055   EU patent No.  No. 1,338,198   Japanese trademark registration No.  No. 4,823,423   US trademark registration No.  No. 4,823,423   EU trademark registration No.  No. 3,736,758  CIEA의 NOG 마우스는 In-Vivo Science Inc.를 통하여 한국에 공급되고 있습니다.  참고 논문: Ito M et al. Blood 2002  Characteristics of the NOG mouse  Multiple immunodeficiencies that are principally derived from three strains of mice:       1) NOD/Shi inbred strain    2) Scid mouse    3) IL-2Rrnull mutation  Lacking T and B cells - from Scid & IL-2Rrnull mutation  Lacking Natural Killer (NK) cells - from NOD/Shi inbred strain  Reduced dendritic cell function - from IL-2Rrnull mutation  Reduced macrophage function - from NOD/Shi inbred strain  Lacking complement activity - from NOD/Shi inbred strain No T and B cell leakiness associated with aging  Very low incidence of lymphoma (unlike NOD-Scid model)  Does not develop diabetes Model Hair T Cell B Cell NK Cell Nude No Nonfunctional Functional Functional CB17-Scid Yes Nonfunctional Nonfunctional Functional NOD-Scid Yes Nonfunctional Nonfunctional Impaired NOG Yes Nonfunctional Nonfunctional Nonfunctional  Body Weight of the NOG mouse  History of the NOG mouse  Humanized models using the NOG mouse (Humanized mice)  PDOX model.  Human hematopoietic system and human immune system model.  Human liver model.  Human cancer-bearing model.  Human infectious disease model.  GVHD model.  Other models.   PDOX Model  Patient-Derived tumor Orthotopic Xenograft (PDOX) model.  PDOX for individualized Cancer therapy.  Only PDOX models can metastasize similar to clinical cancer.  All drug tested in PDOX.  All patient tumor types grown in PDOX.  Patient Phase -> Engraftment Phase -> Expansion Phase -> Treatment Phase / Boologic studies / Biomarker discovery / Perpetul Bank    Oncology Model  The CIEA NOG mouse engrafts cell lines other models cannot Cell Line Cancer Cell Type Comparison Line Comparison Line Take Rate NOG Take Rate U26612 human multiple myeloma CB-17 Scid 0/5 20/20 U26612 human multiple myeloma NOD Scid 0/5 20/20 A205817* human melanoma NOD Scid 0/6 6/6 A37517* human melanoma NOD Scid 0/9 8/9 G36117* human melanoma NOD Scid 0/6 2/6 HMY-117* human melanoma NOD Scid 0/8 2/8 AspC-136** human pancreatic cancer NOD Scid 8/9 9/9 BxPC-336** human pancreatic cancer NOD Scid 0/8 8/8 Capan-136** human pancreatic cancer NOD Scid 0/10 9/10 MAPaCa-236** human pancreatic cancer NOD Scid 0/10 10/10 PANC-136** human pancreatic cancer NOD Scid 0/10 8/8  NOG 마우스의 주문  일본 CIEA NOG 마우스  5~6 주령의 동물로 공급이 가능합니다. (4, 7주령의 동물은 사용 목적에 따라 공급 가능 여부 확인이 필요합니다.)  임신 동물과 Breeding Pair는 공급이 불가합니다.  공급 불가 항목은 실험 목적에 따라 협의가 가능합니다.  LMO 동물로 실제 사용 기관에서 사전 신고가 필요합니다.  매주 1회 수입 통관 후 공급됩니다.  주문하시는 마릿 수에 따라 단가가 다른 동물이므로 문의를 바랍니다.  문의 주시면 동물에 대한 자세한 정보를 보내드리겠습니다.  http://www.ciea.or.jp/en/nog_mouse.html Humanized mouse, Humanized mice