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> 실험동물 > Humanized Mouse

일본 CIEA (Central Institute for Experimental Animals)의 NOG 마우스를 공급합니다.

 

 NOG mouse




  Developed by CIEA in 2002  
  Formal name  NOD.Cg-Prkdcscid II2rgtm1Sug/Jic
  Abbreviated name  NOD/Shi-scid,IL-2Rγnull
(NOD-scidIl2Rgnull, NOD scid gamma)
  Japanese patent No.  No. 3,753,321
  US patent No.  No. 7,145,055
  EU patent No.  No. 1,338,198
  Japanese trademark registration No.  No. 4,823,423
  US trademark registration No.  No. 4,823,423
  EU trademark registration No.  No. 3,736,758

 CIEA의 NOG 마우스는 In-Vivo Science Inc.의 대리점인 새론바이오와 코아텍을 통하여 한국에 공급되고 있습니다.


 Characteristics of the NOG mouse

 Multiple immunodeficiencies that are principally derived from three strains of mice:
  
   1) NOD/Shi inbred strain
   2) Scid mouse
   3) IL-2Rrnull mutation

 Lacking T and B cells - from Scid & IL-2Rrnull mutation

 Lacking natural killer (NK) cells - from NOD/Shi inbred strain

 Reduced dendritic cell function - from IL-2Rrnull mutation

 Reduced macrophage function - from NOD/Shi inbred strain

 Lacking complement activity - from NOD/Shi inbred strain

No T and B cell leakiness associated with aging

 Very low incidence of lymphoma (unlike NOD-Scid model)

Model

Hair

T Cell

B Cell

NK Cell

Nude

No

Nonfunctional

Functional

Functional

CB17-Scid

Yes

Nonfunctional

Nonfunctional

Functional

NOD-Scid

Yes

Nonfunctional

Nonfunctional

Impaired

NOG

Yes

Nonfunctional

Nonfunctional

Nonfunctional




 Body Weight of the NOG mouse



 History of the NOG mouse


 Humanized models using the NOG mouse (Humanized mice)

 PDOX model.

 
Human hematopoietic system and human immune system model.

 Human liver model.


 Human cancer-bearing model.

 Human infectious disease model.


 GVHD model.


 Other models


 PDOX Model

 Patient-Derived tumor Orthotopic Xenograft (PDOX) model.

 PDOX for 
individualized Cancer therapy.

 Only PDOX models can metastasize similar to clinical cancer.


 All drug tested in PDOX.

 All patient tumor types grown in PDOX.


 Patient Phase -> Engraftment Phase -> Expansion Phase
-> Treatment Phase / Boologic studies / Biomarker discovery / Perpetul Bank


 
 Oncology Model

 The CIEA NOG mouse engrafts cell lines other models cannot

Cell Line

Cancer Cell Type

Comparison Line

Comparison Line
Take Rate

NOG
Take Rate

U26612

human multiple myeloma

CB-17 Scid

0/5

20/20

U26612

human multiple myeloma

NOD Scid

0/5

20/20

A205817*

human melanoma

NOD Scid

0/6

6/6

A37517*

human melanoma

NOD Scid

0/9

8/9

G36117*

human melanoma

NOD Scid

0/6

2/6

HMY-117*

human melanoma

NOD Scid

0/8

2/8

AspC-136**

human pancreatic cancer

NOD Scid

8/9

9/9

BxPC-336**

human pancreatic cancer

NOD Scid

0/8

8/8

Capan-136**

human pancreatic cancer

NOD Scid

0/10

9/10

MAPaCa-236**

human pancreatic cancer

NOD Scid

0/10

10/10

PANC-136**

human pancreatic cancer

NOD Scid

0/10

8/8



 NOG 마우스의 주문

 
일본 CIEA NOG 마우스

* 5~7주령의 동물로 공급이 가능합니다. (7주령의 동물은 미리 재고 확인이 필요합니다.)

* 임신 동물과 Breeding Pair는 공급이 불가합니다.

* 공급 불가 항목은 실험 목적에 따라 협의가 가능합니다.

* LMO 동물로 사전 신고가 필요하며 새론바이오에서 대행이 가능합니다.

* 매주 수요일에 수입 통관 후 공급됩니다.



 주문하시는 마릿 수에 따라 단가가 다른 동물이므로 문의를 바랍니다.

 문의 주시면 동물에 대한 자세한 정보를 보내드리겠습니다.

 http://www.ciea.or.jp/en/nog_mouse.html

Humanized mouse, Humanized mice

 

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