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> 실험동물 > Humanized Mouse

일본 CIEA (Central Institute for Experimental Animals)의 NOG 마우스(Humanized mouse)를 공급합니다.

 

 

 NOG mouse

 Developed by CIEA in 1998.

 Formal name: NOD.Cg-Prkdcscid II2rgtm1Sug/Jic

 Abbreviated name: NOD/Shi-scid,IL-2Rγnull

 Patent.
Japanese patent No. 3,753,321
US patent No. 7,145,055
EU patent No. 1,338,198

 Trademark Registration.
Japanese trademark registration No. 4,823,423
US trademark registration No. 3,118,040
EU trademark registration No. 3,736,758


 Characteristics of the NOG mouse

 Multiple immunodeficiencies that are principally derived from three strains of mice:
  
   1) NOD/Shi inbred strain
   2) Scid mouse
   3) IL-2Rrnull mutation

 Lacking T and B cells - from Scid & IL-2Rrnull mutation

 Lacking natural killer (NK) cells - from NOD/Shi inbred strain

 Reduced dendritic cell function - from IL-2Rrnull mutation

 Reduced macrophage function - from NOD/Shi inbred strain

 Lacking complement activity - from NOD/Shi inbred strain

No T and B cell leakiness associated with aging

 Very low incidence of lymphoma (unlike NOD-Scid model)

Model

Hair

T Cell

B Cell

NK Cell

Nude

No

Nonfunctional

Functional

Functional

CB17-Scid

Yes

Nonfunctional

Nonfunctional

Functional

NOD-Scid

Yes

Nonfunctional

Nonfunctional

Impaired

NOG

Yes

Nonfunctional

Nonfunctional

Nonfunctional


 History of the NOG mouse


 Humanized models using the NOG mouse (Humanized mice)

 PDOX model.

 
Human hematopoietic system and human immune system model.

 Human liver model.


 Human cancer-bearing model.

 Human infectious disease model.


 GVHD model.


 Other models


 PDOX Model

 Patient-Derived tumor Orthotopic Xenograft (PDOX) model.

 PDOX for 
individualized Cancer therapy.

 Only PDOX models can metastasize similar to clinical cancer.

 All drug tested in PDOX.

 All patient tumor types grown in PDOX.


 Patient Phase -> Engraftment Phase -> Expansion Phase
-> Treatment Phase / Boologic studies / Biomarker discovery / Perpetul Bank


 
 Oncology Model

 The CIEA NOG mouse engrafts cell lines other models cannot

Cell Line

Cancer Cell Type

Comparison Line

Comparison Line
Take Rate

NOG
Take Rate

U26612

human multiple myeloma

CB-17 Scid

0/5

20/20

U26612

human multiple myeloma

NOD Scid

0/5

20/20

A205817*

human melanoma

NOD Scid

0/6

6/6

A37517*

human melanoma

NOD Scid

0/9

8/9

G36117*

human melanoma

NOD Scid

0/6

2/6

HMY-117*

human melanoma

NOD Scid

0/8

2/8

AspC-136**

human pancreatic cancer

NOD Scid

8/9

9/9

BxPC-336**

human pancreatic cancer

NOD Scid

0/8

8/8

Capan-136**

human pancreatic cancer

NOD Scid

0/10

9/10

MAPaCa-236**

human pancreatic cancer

NOD Scid

0/10

10/10

PANC-136**

human pancreatic cancer

NOD Scid

0/10

8/8



 NOG mouse 단가

Heads

마리 당 단가

비고

10

문의

 5~6Weeks 공급 가능

20

-

 Breeding Pair 공급 불가

30

-

 공급 불가 항목은 실험 목적에 따라 협의 가능

40

-

 부가가치세 별도 입니다.

50

-

 환율에 따른 단가 변동이 있을 수 있습니다.


* 상기 단가는 일본 CIEA Facility 동물의 단가입니다.

* NOG 마우스는 수입 시 묶음 통관으로 연구자분께 저렴하게 공급 됩니다.


 Second Generation of the NOG Model (Humanized mice)

                 Strain                Research Purpose
  1   hlL-4 Tg-NOG   Th cell analysis
  2   hlL-2 Tg-NOG   NK cell development
  3   hlL-4 Tg-BALB/c-dKO   Model for HlV-1
  4   hlL-4 Tg-CB-17-scid   Model for HlV-1
  5   hGM-CSF/hlL-3 Tg-NOG   Myeloid cell development
  6   Jagged1Tg-NOG   Generation of HSC niche
  7   Delta1 Tg-NOG   Generation of HSC niche
  8   SDF1a Tg-NOG   Generation of HSC niche
  9   SDF1b Tg-NOG   Generation of HSC niche
 10   Ncad Tg-NOG   Generation of HSC niche
 11   Ang1 Tg-NOG   Generation of HSC niche
 12   NOG-Wv/Wv.Wv/+   Enhancement of human cell reconstitution
 13   NOG-W/+   Enhancement of human cell reconstitution
 14   NOG-Wsh/Wsh   Mouse mast cell deficiency
 18   HLA-DRA/B (0405) Tg-NOG   Human HLA DR expression
 19   mlFNg Tg-NOG   Analysis of immunodeficency in NOG mice
 23   NOD-RAG2. gc dKO   Alternative NOG
 24   NOD-RAG2 KO   lmmunodeficient
 25   NOD-gc KO   lmmunodeficient
 26   BALB/c-RAG2, gc dKO (ClEA BRG
  mouse. Taconic model 11503)
  Alternative NOG, higher radiation tolerance
 27   NOG-Hr   NOG without hair
 28   BALB/c-RAG2, gc dKO-Nude   BRG without hair
 29   GFP Tg-NOG   Systemic expression of GFP in NOG
 30   UPA Tg-NOG   Human liver replacement NOG
 31   TK Tg-NOG   Human liver replacement NOG



 주문하시는 마릿 수에 따라 단가가 다른 동물이므로 문의를 바랍니다.

 문의 주시면 동물에 대한 자세한 정보를 보내드리겠습니다.

 http://www.ciea.or.jp/en/nog_mouse.html

Humanized mouse, Humanized mice

 

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