인간 조발성 노화 증후군 모델 동물 (Human Premature Geriatric Syndrome Model Mouse)    klotho/Jcl (Nomenclature: C3;B6-KlTg(SLC9A1)/Jcl)    Origin  klotho mouse was found among a mutant group from the mutant gene introduced chimeric mice executed by Dr. Yoichi Nabeshima.  The klotho gene was then identified as a cording of new I type membrane protein with having a signal sequence at the N terminal and transmembrane domain structure at the C terminal and relating calcium controlling in vivo mainly.  CLEA received the strain from Dr. Nabeshima and started its sales from 2002.     Characteristic  kl/k mouse grows normal until 3 to 4 weeks of age, then shows growth retardation after weaning, and dies around 8 to 9 weeks of age.  The external appearance is normal except backward curvature.  The other characteristics are as below: • Hypokinesia and dysbasia • Thymic sexual organ and atrophy • Arteriosclerosis • Osteoporosis • Ectopic calcification • Dermatrophy • Emphysema pulmonum • Pituitary gland abnormality  주문하시는 마릿 수에 따라 단가가 다른 동물이므로 문의를 바랍니다.  추가 정보가 필요 시 연락주시기 바랍니다.  https://www.clea-japan.com/en/products/genetically_modified/item_a0210