Our R&D team headed by Dr. Richard Peterson, developer of the ZDF rat, has developed two novel rodent metabolic disease models. Both models, the ZDSD rat and FATZO mouse, are obese and hyperglycemic without mutations in Leptin pathway.
In addition, PCO maintains colonies of pcy and jck mice for sale and for use in contract studies in polycystic kidney disease and in partnership with the PKDF.
PCO사의 Diabetic Rat (ZDSD), Mouse (Fatzo), PKD Mouse (pcy, jck) 특징
Developed by PCO in 2001.
The ZDSD Rat and the FATZO mouse as Translational Models for Obesity, Metabolic Syndrome and Diabetes with intact leptin pathways
The ZDSD rat and the FATZO mouse do not have these mutations but still have obesity, metabolic syndrome and diabetes and the complications of diabetes in models that have intact leptin pathways.
These relatively new models appear to be significantly more translational than the traditional models mentioned above.
Most rodent models of type 2 diabetes have a monogenetic mutation that is responsible for the initiation of obesity and subsequent insulin resistance.
The two most common obesity causing mutations are:
• the leptin receptor - Zucker Fatty; ZF rat - Zucker Diabetic Fatty; ZDF rat - db/db mouse
> 실험동물 > ZDSD
미국 PCO (PreClinOmics) 사의 질환동물을 공급합니다.
Rodent Models from PreClinOmics
