실험동물
NOG / CIEA / Japan
Envigo
CLEA / Japan
ZDSD
수술동물
기타동물
 

> 실험동물 > ZDSD

 미국 PCO (PreClinOmics) 사의 질환동물을 공급합니다.


 Rodent Models from PreClinOmics

 Our R&D team headed by Dr. Richard Peterson, developer of the ZDF rat, has developed two novel rodent metabolic disease models. Both models, the
ZDSD rat and FATZO mouse, are obese and hyperglycemic without mutations in Leptin pathway.

 In addition, PCO maintains colonies of pcy and jck mice for sale and for use in contract studies in polycystic kidney disease and in partnership with the PKDF.

 Diabetic rat: ZDSD

 Diabetic mouse: Fatzo

 Polycystic Kidney Disease (PKD mouse): pcy, jck


   PCO사의 Diabetic Rat (ZDSD), Mouse (Fatzo), PKD Mouse (pcy, jck) 특징

 Developed by PCO in 2001.

 The ZDSD Rat and the FATZO mouse as Translational
Models for Obesity, Metabolic Syndrome and Diabetes with intact leptin pathways
 
 The ZDSD rat and the FATZO mouse do not have these mutations but still have obesity, metabolic syndrome and diabetes and the complications of diabetes in models that have intact leptin pathways.

These relatively new models appear to be significantly more translational than the traditional models mentioned above.

Most rodent models of type 2 diabetes have a monogenetic mutation that is responsible for the initiation of obesity and subsequent insulin resistance.

  The two most common obesity causing mutations are:

  • the leptin receptor
     - Zucker Fatty; ZF rat
     - Zucker Diabetic Fatty; ZDF rat
     - db/db mouse
• the leptin molecule
   - ob/ob mouse









 
  
 



 주문하시는 마릿 수에 따라 단가가 다른 동물이므로 문의를 바랍니다.

 문의 주시면 동물에 대한 자세한 정보를 보내드리겠습니다.

 http://www.preclinomics.com/genetic-models/

 

경기도 의왕시 청계동 996-5 1층 TEL : 031-425-6300 FAX : 031-425-6677


Copyright by blueweb.co.kr. All Rights Reserved.